SpringerProtocols: Abstract: Macromolecular Delivery Across the BloodBrain Barrier

13. Macromolecular Delivery Across the Blood–Brain Barrier

By: Kullervo Hynynen¹

Abstract

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The delivery of macromolecules into the central nervous system (CNS) via the blood stream is seriously limited by the blood–brain barrier (BBB). Noninvasive, transient, and local image-guided blood–brain barrier disruption (BBBD) can be accomplished using focused ultrasound exposure with intravascular injection of pre-formed microbubbles. A detailed description of the method for MRI-guided focal BBBD in animals will be described in this chapter. The method may open a new era in CNS macromolecular drug delivery.

Affiliation(s): (1) Department of Medical Biophysics, University of Toronto and Sunnybrook Health Sciences Centre, 2075 Bayview Ave Toronto, ON, Canada

Book Title: Macromolecular Drug Delivery: Methods and Protocols

Series: Methods in Molecular Biology | Volume: 480 | Year: 2009 | Page Range: 1-11 | DOI: 10.1007/978-1-59745-429-2_13

Subject: Pharmacology/Toxicology

Key Words: Ultrasonics - Magnetic resonance imaging (MRI) - Drug delivery systems - Ultrasound contrast agents - Blood–brain barrier

References

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