Springer Protocols: Abstract: Phorbol Esters

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Phorbol Esters

Abstract

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The term phorbol is loosely used to describe a family of naturally occurring compounds referred to as tiglian diterpenes. These are widely distributed in the plant species of the families Euphorbiaceae and Thymelaeaceae. This chapter describes a method for determination of phorbol esters in physic nut (Jatropha curcas), which belongs to Euphorbiaceae family.

Book Title: Plant Secondary Metabolites

Series: Methods in Molecular Biology | Volume: 393 | Pub. Date: Jul-06-2007 | Page Range: 101-105 | DOI: 10.1007/978-1-59745-425-4_17

Subject: Plant Sciences

Key Words: Phorbol esters - Jatropha curcas seed kernels - Euphorbiaceae - carcinogenic - mutagenic - giddiness - phorbol-12-myristate 13-acetate - HPLC - O-phosphoric acid - acetonitrile - tetrahydrofuran

References

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1.	Makkar, H. P. S., and Becker, K. (1998) Jatropha curcas toxicity: identification of toxic principle(s), in Toxic Plants and Other Natural Toxicants, Garland, T., and Barr, A.C., eds., CAB International, New York, pp. 554–558.

2.	Makkar, H. P. S., and Becker, K. (1999) Nutritional studies on rats and fish (carp Cyprinus carpio) fed diets containing unheated and heated Jatropha curcas meal of a non-toxic provenance. Plant Foods Human Nutr. 53, 183–192.

3.	Hirota, M., Suttajit, M., Suguri, H., et al. (1988) A new tumor promoter from the seed oil of Jatropha curcas L., an intramolecular diester of 12-desoxy-16-hydroxyphorbol. Cancer Res. 48, 5800–5804.

4.	Adolf, W., Opferkuch, H. J., and Hecker, E. (1984) Irritant phorbol derivatives from four Jatropha species. Phytochemistry 23, 129–132.

5.	Makkar, H. P. S., Becker, K., Sporer, F., and Wink, M. (1997) Studies on nutritive potential and toxic constituents of different provenances of Jatropha curcas. J. Agric. Food Chem. 45, 3152–3157.

6.	Makkar, H. P. S., Becker, K., and Schmook, B. (1998) Edible provenances of Jatropha curcas from Quintana Roo state of Mexico and effect of roasting on antinutrient and toxic factors in seeds. Plant Foods Hum. Nutr. 52, 31–36.

7.	Makkar, H. P. S., Aderibigbe, A. O., and Becker, K. (1998) Comparative evaluation of non-toxic and toxic varieties of Jatropha curcas for chemical composition, digestibility, protein degradability and toxic factors. Food Chem. 62, 207–215.

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