L-DOPA (L-3,4-Dihydroxyphenylalanine)
The nonprotein amino acid, 3,4-dihydroxyphenylalanine (L-DOPA) (Fig. 1) is present in high concentrations (about 3–6%) in Mucuna spp. The in vitro addition of L-DOPA to the red blood cells from individuals deficient in glucose 6-phosphate dehydrogenase decrease the glutathione content
in red blood cells and this ultimately induces the favisum (hemolytic anemia; breakup of red blood cells). The inclusion of
L-DOPA in fish feed has been reported to signifi- cantly reduce the growth performance. L-DOPA is susceptible to oxidation, giving a semiquinone that complexes with proteins. This decreases protein digestibility.
On the other hand, it has been used for the treatment of Parkinson’s disease because of its being a precursor of dopamine,
a neurotransmitter.
Series: Methods in Molecular Biology | Volume: 393 | Pub. Date: Jul-06-2007 | Page Range: 51-53 | DOI: 10.1007/978-1-59745-425-4_10