Contents of this article

Useful Tools
L-DOPA (L-3,4-Dihydroxyphenylalanine)
Abstract
The nonprotein amino acid, 3,4-dihydroxyphenylalanine (L-DOPA) (Fig. 1) is present in high concentrations (about 3–6%) in Mucuna spp. The in vitro addition of L-DOPA to the red blood cells from individuals deficient in glucose 6-phosphate dehydrogenase decrease the glutathione content in red blood cells and this ultimately induces the favisum (hemolytic anemia; breakup of red blood cells). The inclusion of L-DOPA in fish feed has been reported to signifi- cantly reduce the growth performance. L-DOPA is susceptible to oxidation, giving a semiquinone that complexes with proteins. This decreases protein digestibility. On the other hand, it has been used for the treatment of Parkinson’s disease because of its being a precursor of dopamine, a neurotransmitter.
Series: Methods in Molecular Biology  |  Volume: 393  |  Pub. Date: Jul-06-2007  |  Page Range: 51-53  |  DOI: 10.1007/978-1-59745-425-4_10
Subject:  Plant Sciences
Key Words: L-DOPA - 3,4-dihydroxyphenylalanine - favisum - hemolytic anemia - glutathione content - protein digestibility - semiquinone - Parkinson’s disease - Mucuna spp. - Vicia faba - HPLC - C18 nucleosil 120 column
Comments (Loading...)
Loading...