| 1. |
Leibson, P. J., Loken, M. R., Runem, S., and Schreiber, H. (1999) Clonal evolution of myeloma cells leads to quantitative
changes in immunoglobulin secretion and surface antigen expression. Proc. Natl. Acad. Sci. USA
76(6), 2937–2941.
|
| |
| 2. |
Meilhoc, E., Witturp, K. D., and Bailey, J. E. (1989) Application of flow cytometric measurement of surface IgG in kinetic
analysis of monoclonal antibody and secretion by murine hybridoma cells. J. Immunol. Methods
121, 167–174.
|
| |
| 3. |
Dalili, M. and Ollis, D. F. (1990) A flow cytometric analysis of hybridoma growth and monoclonal antibody production. Biotechnol. Bioeng.
36(1), 64–73.
|
| |
| 4. |
Marder, P., Maciak, R. S., Fouts, R. L., Baker, R. S., and Starling, J. J. (1990) Selective cloning of hybridoma cells for
enhanced immunoglobulin production using flow cytometric cell sorting and automated laser nephelometry. Cytometry
11(4), 498–505.
|
| |
| 5. |
Sen, S., Hu, W. S., and Srienc, F. (1990) Flow cytometric study of hybridoma cell culture: correlation between cell surface
fluorescence and IgG production rate. Enzyme Microb. Technol.
12, 571–576.
|
| |
| 6. |
Al-Rubeai, M., Emery, A. N., and Chalder, S. (1991) Flow cytometric study of cultured mammalian cells. J. Biotechnol.
19, 67–82.
|
| |
| 7. |
Leno, M., Merten, O.-W., Vuiller, F., and Hache, J. (1991) IgG production in hybridoma batch culture: kinetics of IgG mRNA,
cytoplasmic-, secreted-and membrane-bound antibody levels. J. Biotechnol.
20, 301–312.
|
| |
| 8. |
McKinney, K. L., Dilwith, R., and Belfort, G. (1991) Manipulation of heterogeneous hybridoma cultures for overproduction of
monoclonal-antibodies. Biotechnol. Prog.
7(5), 445–454.
|
| |
| 9. |
Park, S. H. and Ryu, D. Y. (1994) Cell cycle kinetics and monoclonal antibody productivity in hybridoma cells during perfusion
culture. Biotechnol. Bioeng.
44, 361–367.
|
| |
| 10. |
Altshuler, G. L., Dilwith, R., Sowek, J., and Belfort, G. (1986) Hybridoma analysis at cellular level. Biotechnol. Bioeng. Symp.
17, 725–736.
|
| |
| 11. |
Al-Rubeai, M. and Emery, A. N. (1990) Mechanisms and kinetics of monoclonal-antibody synthesis and secretion in synchronous
and asynchronous hybridoma cell culture. J. Biotechnol.
16(1–2), 67–86.
|
| |
| 12. |
Ramirez, O. T. and Mutharason, R. (1990) Cell cycle and growth phase dependent variations in size distributions, antibody
productivity, and oxygen demand in hybridoma cultures. Biotechnol. Bioeng.
36, 839–848.
|
| |
| 13. |
Kromenaker, S. J. and Srienc, F (1991) Cell cycle-dependent protein accumulation by producer and non-producer murine hybridoma
cell lines: A population analysis. Biotechnol. Bioeng.
38, 665–677.
|
| |
| 14. |
Hayter, P. M., Kirkby, N. F., and Spier, R. E. (1992) Relationship between hybridoma growth and monoclonal antibody production.
Enzyme Microbiol. Technol.
14, 454–461.
|
| |
| 15. |
Linardos, T. I., Kalogerakis, N., and Behie, L. A. (1992) Cell cycle model for growth rate and death rate in continuous suspension
hybridoma cultures. Biotechnol. Bioeng.
40, 359–368.
|
| |
| 16. |
Leelavatcharamas, V., Emery, A. N., and Al-Rubeai, M. (1996) Monitoring the proliferative capacity of cultured animal cells
by cell cycle analysis, in Flow Cytometry Application in Cell Culture (Al-Rubeai M. and Emery A. N., eds.), Marcel Dekker Inc., New York, pp. 1–15.
|
| |
| 17. |
Kearns, B., Lindsay, D., Manahan, M., McDowall, J., and Rendeiro, D. (2003) NS0 batch cell culture process characterization:
a case study. Biol. Proc. J.
2(1), 52–57.
|
| |
| 18. |
Carroll, S. (2004) The selection and monitoring of high producing recombinant cell lines using flow cytometry, PhD thesis,
The University of Birmingham.
|
| |
| 19. |
Carroll, S. and Al-Rubeai, M. (2005) ACSD labeling and magnetic cell separation: A rapid method of separating antibody secreting
cells from non-secreting cells. J. Immunol. Methods (1–2), 171–178.
|
| |
| 20. |
Al-Rubeai, M. (1999) Monitoring animal cell growth and productivity by flow cytometry, in Methods in Biotechnology, Vol. 8: Animal Cell Biotechnology (Jenkins, N., ed.), Humana Press Inc., Totowa, NJ, pp. 145–153.
|
| |
| 21. |
Ormerod, M. G. and Imrie, P. R. (1990) How cytometry, in Methods in Molecular Biology, Vol. 5. (Pollard, J. W. and Walker, J. M., eds.), Humana Press Inc., Totowa, NJ, pp. 543–558.
|
| |
| 22. |
Grogan, W. M. and Collins, J. M. (1990) Guide to Flow Cytometry Methods, Marcel Dekker, New York.
|
| |
| 23. |
Merritt, S. E. and Palsson, B. O. (1993) Loss of antibody productivity is highly reproducible in multiple hybridoma subclones.
Biotechnol. Bioeng.
42, 247–250.
|
| |
| 24. |
Borth, N., Strutzenberger, K., Kunert, R., Steinfellner, W., and Katinger, H. (1999) Analysis of changes during subclone development
and ageing of human antibody-producing heterohybridoma cells by Northern blot and flow cytometry. J. Biotechnol.
67, 57–66.
|
| |
| 25. |
Chuck, A. S. and Palsson, B. O. (1992) Population balance between producing and non-producing hybridoma clones is very sensitive
to serum level, state of innoculum, and medium composition. Biotechnol. Bioeng.
39, 354–360.
|
| |
| 26. |
Manz, R., Assenmacher, M., Pfluger, E., Miltenyi S., and Radbruch, A. (1995) Analysis and sorting of live cells according
to secreted molecules, relocated to a cell-surface affinity matrix. Proc. Natl. Acad. Sci. USA
92, 1921–1925.
|
| |
| 27. |
Holmes, P. and Al-Rubeai, M. (1999) Improved cell line development by a high throughput affinity capture surface display technique
to select for high secretors. J. Immunol. Methods
230, 141–147.
|
| |
| 28. |
Borth, N., Zeyda, M., and Katinger, H. (2001) Efficient selection of high-producing subclones during gene amplification of
recombinant Chinese hamster ovary cells by flow cytometry and cell sorting. Biotechnol. Bioeng.
71(4), 266–273.
|
| |
| 29. |
Carroll, S. and Al-Rubeai, M. (2004) The selection of high-producing cell lines using flow cytometry and cell sorting. Expert Opin. Biol. Ther.
4(11), 1821–1829.
|
| |
| 30. |
Lonza Group AG. (2004) Method for selecting antibody expressing cells. EP1415158B1.
|
| |
| 31. |
Al-Rubeai, M., Kloppinger, M., Fertig, G., Emery, A. N., and Miltenburger, H. G. (1992) Monitoring of biosynthetic and metabolic
activity in animal cell culture using flow cytometric methods, in Animal Cell Technology (Spier R., Griffiths, J., and MacDonald, C., eds), Butterworth-Heinemann, pp. 301–307.
|
| |
| 32. |
Welsh, J. P. and Al-Rubeai, M. (1996) The relationship between intracellular pH and cell cycle in cultured animal using SNARF-1
indicator, in Flow Cytometry Applications in Cell Culture (Al-Rubeai, M. and Emery, A. N., eds.), Marcel Dekker, New York, pp. 163–175.
|
| |