Springer Protocols: Abstract: 7. Linkage Disequilibrium Mapping for Complex Disease Genes

7. Linkage Disequilibrium Mapping for Complex Disease Genes

By: Andrew DeWan², Robert J. Klein³, Josephine Hoh²

Abstract

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In this chapter we lay out some background information about gene mapping for human complex traits. The chapter covers issues such as study design, high-throughput genotyping technologies, statistical analysis, and others. Many of the materials are based on and related to our recent experiences in case-control-association studies.

Affiliation(s): (2) Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT
(3) Laboratory of Statistical Genetics, Rockefeller University, New York, NY

Book Title: Linkage Disequilibrium and Association Mapping: Analysis and Applications

Series: Methods in Molecular Biology | Volume: 376 | Pub. Date: Aug-23-2007 | Page Range: 85-107 | DOI: 10.1007/978-1-59745-389-9_7

Subject: Genetics/Genomics

Key Words: LD - SNPs - association - case-control - complex - design - high throughput - genome - power - admixture

References

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