Springer Protocols: Abstract: 1. Linkage Disequilibrium and Association Mapping: An Introduction

1. Linkage Disequilibrium and Association Mapping: An Introduction

By: Andrew R. Collins²

Abstract

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The basis for recent developments on the characterization of the linkage-disequilibrium structure of the genome and the application of association mapping to genes for common human diseases is described. Patterns of linkage disequilibrium are now understood, for a number of human populations, in unprecedented detail. This information not only provides a vital resource for the design and execution of powerful association-mapping studies, but opens new avenues of research into the genetic history of human populations and the effects of natural selection, mutation, and recombination on the genomic landscape.

Affiliation(s): (2) Genetic Epidemiology and Bioinformatics Group, Human Genetics Division, Southampton General Hospital, Southampton, UK

Book Title: Linkage Disequilibrium and Association Mapping: Analysis and Applications

Series: Methods in Molecular Biology | Volume: 376 | Pub. Date: Aug-23-2007 | Page Range: 1-15 | DOI: 10.1007/978-1-59745-389-9_1

Subject: Genetics/Genomics

Key Words: Recombination - linkage mapping - linkage disequilibrium - haplotype blocks - selection - case-control study - candidate regions - genome-wide association

References

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