SpringerProtocols: Abstract: Genetic Epidemiology of Complex Phenotypes

11. Genetic Epidemiology of Complex Phenotypes

By: Lynette Peddle¹, Proton Rahman²

Abstract

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Genetic factors play a substantive role in the susceptibility to common diseases. Due to recent advancements in the characterization of genetic variants and large-scale genotyping platforms, multiple genes have now been identified for common, complex diseases. As a result, there is an immense interest in elucidating genetic factors in complex traits. Therefore, it is important to understand the design as well as the technical and statistical issues of the two most common approaches for gene identification: linkage and association.

Affiliation(s): (1) Senior Scientist, Newfound Genomics, St. Johns, Canada
(2) St. Clares Hospital, 164 LeMarchant Road, St. Johns, Newfoundland, A1C 5B8, Canada

Book Title: Clinical Epidemiology: Practice and Methods

Series: Methods in Molecular Biology | Volume: 473 | Year: 2009 | Page Range: 1-15 | DOI: 10.1007/978-1-59745-385-1_11

Subject: Molecular Medicine

Key Words: Genetic epidemiology - linkage studies - association studies - whole genomewide association scans - genotyping - linkage disequilibrium

References

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