SpringerProtocols: Abstract: Modulation of Apoptosis to Reverse Chemoresistance

Modulation of Apoptosis to Reverse Chemoresistance

By: Gil Mor, Michele K. Montagna, Ayesha B. Alvero

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Interference with the innate apoptotic activity is a hallmark of neoplastic transformation and tumor formation. Modulation of the apoptotic cascade has been proposed as a new approach for the treatment of cancer. In this chapter, we discuss the role of apoptosis in ovarian cancer and the use of phenoxodiol as a model for the regulation of apoptosis and potential use as chemosensitizer for chemoresistant ovarian cancer cells.

Book Title: Apoptosis and Cancer: Methods and Protocols

Series: Methods in Molecular Biology | Volume: 414 | Pub. Date: Oct-11-2007 | Page Range: 1-12 | DOI: 10.1007/978-1-59745-339-4_1

Subject: Cancer Research

Key Words: Apoptosis - ovarian cancer - X-linked inhibitor of apoptosis protein (XIAP) - phenoxodiol - caspases

References

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