SpringerProtocols: Abstract: Gene Expression Profile Analysis of Tumors

Gene Expression Profile Analysis of Tumors

By: Katia Basso^{4 5}, Riccardo Dalla-Favera^{4 5}

Abstract

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Gene expression profiling is a powerful tool to analyze the complexity of cancer biology. Recent methods allow the generation of gene expression profiles for all known genes in the human genome. The genome-wide analysis of the gene expression patterns of neoplastic and normal cells provides insights into: (1) the identification of previously unknown tumor subtypes; (2) the normal cellular counterparts of tumor cells; (3) the identification of cellular pathways that may be affected by malignant transformation; (4) the identification of new diagnostic markers and potential therapeutic targets. This chapter summarizes experimental approaches addressing these goals using examples from studies on B-cell malignancies.

Affiliation(s): (4) Institute of Cancer Genetics, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY
(5) Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY

Book Title: Cancer Genomics and Proteomics: Methods and Protocols

Series: Methods in Molecular Biology | Volume: 383 | Year: 2007 | Page Range: 67-79 | DOI: 10.1007/978-1-59745-335-6_5

Subject: Cancer Research

Key Words: Oligonucleotides arrays - B-cell malignancies - gene expression profiling - gene expression data analysis - molecular classification of tumors - cancer

References

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