SpringerProtocols: Abstract: 6. Mammalian Fertilization is Dependent on Multiple Membrane Fusion Events*

6. Mammalian Fertilization is Dependent on Multiple Membrane Fusion Events*

By: Paul M. Wassarman³, Eveline S. Litscher³

Abstract

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Successful completion of fertilization in mammals is dependent on three membrane fusion events. These are (1) the acrosome reaction of sperm, (2) the fusion of sperm and egg plasma membranes to form a zygote, and (3) the cortical reaction of fertilized eggs. Extensive research into the molecular basis of each of these events has identified candidate proteins and factors involved in fusion of membranes during the mammalian fertilization process. Some of this information is provided here.

Affiliation(s): (3) Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY

Book Title: Cell Fusion: Overviews and Methods

Series: Methods in Molecular Biology | Volume: 475 | Pub. Date: Jul-01-2008 | Page Range: 99-113 | DOI: 10.1007/978-1-59745-250-2_6

Subject: Cell Biology

Key Words: Mammalian fertilization - sperm - eggs - acrosome reaction - sperm–egg fusion - cortical reaction

References

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Additional References
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Dunbar B. S. and O'Rand M.G. (eds.) (1991) A Comparative Overview of Mammalian Fertilization. Plenum Press, New York.

Gwatkin R. B. L. (1977) Fertilization Mechanisms in Man and Mammals. Plenum Press, New York.

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