Springer Protocols: Abstract: Mobilization of Hematopoietic Stem and Progenitor Cells in Mice

Mobilization of Hematopoietic Stem and Progenitor Cells in Mice

By: Simon N. Robinson³, Ronald P. van Os⁴

Abstract

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Animal models have added significantly to our understanding of the mechanism(s) of hematopoietic stem and progenitor cell (HSPC) mobilization. Such models suggest that changes in the interaction between the HSPC and the hematopoietic microenvironmental ‘niche’ (cellular and extracellular components) are critical to the process. The increasing availability of recombinant proteins (growth factors, cytokines, chemokines), antibodies, drugs (agonists and antagonists), and mutant and genetically modified animal models [gene knock-in (KI) and knock-out (KO)] continue to add to the tools available to better understand and manipulate mobilization processes.

Affiliation(s): (3) University of Texas, MD Anderson Cancer Center, Houston, TX
(4) Department of Stem Cell Biology, University Medical Center Groningen, the Netherlands

Book Title: Hematopoietic Stem Cell Protocols

Series: Methods in Molecular Biology | Volume: 430 | Pub. Date: Jan-01-2008 | Page Range: 31-53 | DOI: 10.1007/978-1-59745-182-6_3

Subject: Cell Biology

Key Words: Mouse models - hematopoietic stem and progenitor cell (HSPC) - mobilization - methodologies - endpoints

References

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