SpringerProtocols: Abstract: Comparative Genomics: A Tool to Functionally Annotate Human DNA

Comparative Genomics: A Tool to Functionally Annotate Human DNA

By: Jan-Fang Cheng^{3 4}, James R. Priest^{3 4}, Len A. Pennacchio^{3 4}

Abstract

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The availability of an increasing number of vertebrate genomes has enabled comparative methods to infer functional sequences based on evolutionary constraint. Although this has proved powerful for gene identification, significant progress has also been made in uncovering gene regulatory sequences such as distant acting transcriptional enhancers. These pursuits have led to the development of a variety of valuable databases and resources that should serve as a routine toolbox for biological discovery.

Affiliation(s): (3) Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
(4) Joint Genome Institute, U.S. Department of Energy, Walnut Creek, CA, USA

Book Title: Cardiac Gene Expression: Methods and Protocols

Series: Methods in Molecular Biology | Volume: 366 | Pub. Date: Mar-19-2007 | Page Range: 229-251 | DOI: 10.1007/978-1-59745-030-0_13

Subject: Genetics/Genomics

Key Words: Comparative genomics - gene regulation - enhancer - transcription - databases

References

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