The efficient separation and isolation of recombinant biomolecules from complex and crude feedstock solutions such as fermentation broths and cell culture supernatants has been a challenge for the purification technologists. This challenge has become even greater with the appropriate stringent regulatory requirements of expected levels of purity (>99%) for the injectable biopharmaceutical drugs. This demanding purity criteria imposed on biomolecules for human use have precluded reliance on traditional, nonselective, physicochemical approaches to protein separation. This has contributed to the increased interest in highly selective adsorption techniques such as immunoaffinity adsorption or chromatography as a purification technology.